I loko o ka haneli makahiki o ka mōʻaukala o nā capsules, ua mālama mau ʻo gelatin i ke kūlana o nā mea capsule mainstream ma muli o kona ākea ākea, kūpaʻa kino a me nā waiwai kemika a me nā mea hana maikaʻi loa.Me ka hoʻonui ʻana o ka makemake o ka poʻe no nā capsules, hoʻohana nui ʻia nā capsules hollow i nā ʻano meaʻai, lāʻau lapaʻau a me nā huahana olakino.
Eia naʻe, ʻo ka loaʻa ʻana a me ka laha ʻana o ka maʻi pipi pupule a me ka maʻi wāwae-a-waha e hoʻomaka ai ka hopohopo e pili ana i nā huahana holoholona.ʻO ka mea maʻamau o ka gelatin ʻo ia ka iwi a me ka ʻili o nā pipi a me nā puaʻa, a ua hoʻohuli mālie ka poʻe i kona pilikia.I mea e hōʻemi ai i ka pōʻino palekana o ka hollow capsule raw material, hoʻomau ka poʻe akamai o ka ʻoihana i ka noiʻi ʻana a me ka hoʻomohala ʻana i nā mea kanu capsule kūpono.
Eia kekahi, me ka hoʻonui ʻana o nā ʻano capsules, ʻo ka ʻokoʻa o kā lākou ʻike e hoʻomaopopo i ka poʻe aia nā pilikia kūpono ma waena o nā capsules hollow gelatin a me kekahi mau mea me nā waiwai kūikawā.No ka laʻana, ʻo nā mea i loaʻa nā pūʻulu aldehyde a i ʻole ka hana ʻana e hana i nā pūʻulu aldehyde ma lalo o kekahi mau kūlana hiki ke alakaʻi i ka hui ʻana o ka gelatin;ʻO nā mea i loko me ka hoʻohaʻahaʻa ikaika hiki ke loaʻa ka hopena Maillard me ka gelatin;ʻO ka maʻiʻo me ka hygroscopicity ikaika e hoʻolilo i ka pūpū o Ming capsule i ka wai a nalowale kona paʻakikī kumu.ʻO ka paʻa o ka gelatin hollow capsule e hoʻonui i ka nānā ʻana i nā mea capsule hou.
He aha nā mea kanu i loaʻa i nā mea kanu kūpono no ka hana ʻana i nā capsules paʻakikī hollow?Ua ho'āʻo nui nā kānaka.No ka palapala palapala patent Kina: 200810061238 X i noi ʻia no ka lawe ʻana i ka cellulose sodium sulfate e like me ka mea capsule nui;200510013285.3 no ka lawe ʻana i ka starch a i ʻole ka haku ʻana i ka starch ma ke ʻano he mea capsule nui;Ua hōʻike ʻo Wang GM [1] ua hana ʻia nā capsule hollow mai nā capsules chitosan;ʻO Zhang Xiaoju et al.[2] hōʻike i nā huahana me Konjac soybean protein ma ke ʻano he mea capsule nui.ʻOiaʻiʻo, ʻo nā mea i aʻo nui ʻia he mau mea cellulose.I waena o lākou, ua hoʻokumu ʻia nā capsule hollow i hana ʻia me ka hydroxypropyl methylcellulose (HPMC) i ka hana nui.
Hoʻohana nui ʻia ka HPMC i ka ʻai a me ka lāʻau lapaʻau.He mea hoʻohana maʻamau i ka lāʻau lapaʻau, i komo i loko o Pharmacopoeia o nā ʻāina like ʻole;Ua ʻae ʻo FDA a me EU i ka HPMC ma ke ʻano he mea hoʻohui meaʻai pololei a ʻole;He mea palekana ka Gras, No. GRN 000213;Wahi a JECFA database, INS no.464, ʻaʻohe palena o ka nui o kēlā me kēia lā o HPMC;I ka makahiki 1997, ua ʻae ʻia e ka Ministry of Health o Kina ma ke ʻano he meaʻai meaʻai a me ka mānoanoa (No. 20), e pili ana i nā ʻano meaʻai āpau a hoʻohui ʻia e like me nā koi hana [2-9].Ma muli o ka ʻokoʻa o nā waiwai ma waena o ka HPMC a me ka gelatin, ʻoi aku ka paʻakikī o ka ʻōlelo ʻana o ka HPMC hollow capsule, a pono e hoʻohui ʻia kekahi mau gelling agents, e like me ka Arabic gum, carrageenan (seaweed gum), starch, etc.
ʻO ka HPMC hollow capsule he huahana me ka manaʻo kūlohelohe.ʻIke ʻia kāna ʻenehana waiwai a me ka hana ʻana e nā hui Iudaio, Islam a me nā mea kanu.Hiki iā ia ke hoʻokō i nā pono o nā poʻe me nā hoʻomana like ʻole a me nā ʻano ʻai, a loaʻa ka ʻae kiʻekiʻe.Eia kekahi, loaʻa i nā capsule hollow HPMC nā waiwai kūʻokoʻa:
1.Low wai maʻiʻo - ma kahi o 60% haʻahaʻa ma mua o gelatin hollow capsule
ʻO ka nui o ka wai o ka gelatin hollow capsules he 12.5% - 17.5% [10].Pono e mālama ʻia ka mahana a me ka haʻahaʻa o ke kaiapuni i loko o kahi kūpono kūpono i ka wā o ka hana ʻana, ka lawe ʻana, ka hoʻohana ʻana a me ka mālama ʻana i nā capsules hollow.ʻO ka mahana kūpono he 15-25 ℃ a ʻo ka haʻahaʻa pili he 35% - 65%, i hiki ke mālama ʻia ka hana o ka huahana no ka manawa lōʻihi.He haʻahaʻa loa ka maʻiʻo wai o ka membrane HPMC, maʻamau 4% - 5%, aia ma kahi o 60% haʻahaʻa ma mua o ka gelatin hollow capsule (Fig. 1).ʻO ka hoʻololi ʻana i ka wai me ke kaiapuni i ka wā mālama lōʻihi e hoʻonui i ka ʻike wai o ka HPMC hollow capsule i loko o ka pahu i ʻōlelo ʻia, akā ʻaʻole ia e ʻoi aku ma mua o 9% i loko o 5 mau makahiki.
Fig1.Hoʻohālikelike LOD o nā pūpū HMPC a me Gelatin ma lalo o nā RH like ʻole
ʻO ke ʻano o ka haʻahaʻa wai haʻahaʻa ka HPMC hollow capsule kūpono no ka hoʻopiha ʻana i nā mea hygroscopic a i ʻole nā wai e hoʻolōʻihi i ke ola o ka huahana.
2. High toughness, ʻaʻohe brittleness
E like me ka mea i ʻōlelo ʻia ma luna nei, loaʻa i ka kiʻiʻoniʻoni gelatin kahi ʻano maʻamau.Inā haʻahaʻa ia ma mua o kēia palena, ʻoi aku ka palupalu o ke kiʻi gelatin.ʻO nā capsules hollow gelatin maʻamau me ka ʻole o nā mea hoʻohui i loaʻa ka pilikia o ka brittleness ma mua o 10% i ka wā he 10% ka nui o ka wai;Ke hoʻomau nei ka emi ʻana o ka wai i ka 5%, hiki mai ka brittleness 100%.ʻO ka hoʻohālikelike, ʻoi aku ka maikaʻi o ka paʻakikī o ka HPMC hollow capsules, a mālama lākou i ka hana maikaʻi ʻoiai inā he haʻahaʻa ka haʻahaʻa o ke kaiapuni (Fig. 3).ʻOiaʻiʻo, ʻo ka embrittlement rate o HPMC hollow capsules me nā ʻōlelo kuhikuhi ma lalo o ka haʻahaʻa haʻahaʻa e hōʻike i nā ʻokoʻa nui.
ʻO ka mea ʻē aʻe, ʻo nā capsules hollow gelatin i hoʻokomo ʻia i kahi wahi haʻahaʻa kiʻekiʻe e palupalu, deform a hāʻule paha ma hope o ka lawe ʻana i ka wai.Hiki i ka HPMC hollow capsule ke mālama i ke ʻano maikaʻi a me ka hana ma lalo o ke kūlana o ka haʻahaʻa kiʻekiʻe.No laila, hiki i ka HPMC hollow capsule ke hoʻololi i ke kaiapuni.Ke uhi ka wahi kūʻai o ka huahana i nā ʻāpana climatic like ʻole a i ʻole nā kūlana mālama ʻana, ʻoi aku ka nui o kēia pono o ka HMPC hollow capsule.
3.Strong kemika paʻa
ʻO ka hopena crosslinking o nā capsules gelatin he pilikia koʻikoʻi i loaʻa i ka hoʻomākaukau ʻana o ka capsule.Ma muli o ka hui ʻana o ka aldehyde o ka ʻike me ka hui amino o nā waikawa amino i loko o ka gelatin e hana i kahi ʻōnaehana pūnaewele, paʻakikī ka hoʻoheheʻe ʻana o ka pūpū capsule ma lalo o ke ʻano o ka dissolution in vitro, e pili ana i ka hoʻokuʻu ʻana i nā lāʻau lapaʻau.ʻO ka Hydroxypropyl methylcellulose he cellulose derivative, he mea kemika inert a maikaʻi loa ia me ka nui o nā mea.No laila, ʻaʻohe pilikia o ka hollow capsule HPMC i ka hoʻopili ʻana i ka hopena a me ke kūpaʻa kemika kiʻekiʻe
4.Good uhi hana
Hoʻohana ʻia nā capsules enteric coated no nā lāʻau maʻalahi e hōʻino ʻia e ka ʻakika ʻōpū, hoʻonāukiuki i ka mucosa o ka ʻōpū a i ʻole ka hoʻokele pono ʻia.ʻO ka ʻenehana i ʻae ʻia ma ka honua o nā capsules i uhi ʻia e enteric ka uhi holoʻokoʻa o nā pellets i uhi ʻia a me nā capsules.Hōʻike ka HPMC hollow capsule i nā pono kūʻokoʻa i ka uhi holoʻokoʻa o ka capsule.
Hōʻike ka noiʻi ma muli o ka ʻili o ka HPMC hollow capsule, ʻoi aku ka kiʻekiʻe o ka pilina me ka nui o nā mea hoʻopili enteric ma mua o ka gelatin, a ʻoi aku ka maikaʻi o ka hoʻopili ʻana a me ke kūlike o nā mea uhi ma mua o ka gelatin, ʻoi aku ka hilinaʻi o ka uhi ʻana o ka hui ʻana o ke kino. ua hoʻomaikaʻi nui ʻia.Ua hōʻike ʻia ka hoʻāʻo in vitro dissolution he haʻahaʻa ka permeability o ka capsule HPMC i loko o ka ʻōpū a ua hoʻokuʻu maikaʻi ʻia i loko o ka ʻōpū.
Ka hopena
ʻO nā hiʻohiʻona o ka HPMC hollow capsule i hoʻonui i kāna kahua noi.Mai nā huahana kūlohelohe a hiki i ka maʻemaʻe a i ʻole nā mea hygroscopic, loaʻa iā ia nā noi kūʻokoʻa ma ke kahua o ka pauka maloʻo inhalants a me ka uhi enteric.Pono e hoʻomaopopo ʻia ʻo HPMC hollow capsules i kēia manawa ma ka mākeke ma ka home a me nā ʻāina ʻē he kiʻekiʻe ka oxygen permeability a ʻoi aku ka lohi o ka disintegration ma mua o ka gelatin hollow capsules, akā like ko lākou bioavailability i vivo [11], pono e noʻonoʻo ʻia i ka noiʻi a me ka hoʻomohala ʻana.
E like me kā mākou e ʻike ai, he ala lōʻihi ka hele ʻana mai ka noiʻi hale hana, hoʻokolohua nui, hana ʻenehana a hiki i ka hoʻolaha mākeke.ʻO ia ke kumu, ma hope o nā makahiki o ka noiʻi ʻana a me ka hoʻomohala ʻana, ua helu maikaʻi ʻia nā huahana capsule hollow i hana ʻia i nā mea kanu.I ka makahiki 1997, ua alakaʻi ʻo Capsugel i ka papa inoa ʻana i ka HPMC hollow capsule vcapstm ma ʻAmelika Hui Pū ʻIa, e hāʻawi ana i kahi koho hou no ka capsule waha.I kēia manawa, ua ʻoi aku ka nui o ke kūʻai aku ʻana o ka HPMC hollow capsules i ka honua ma mua o 20 biliona, a ke ulu nei ma kahi o 25% i kēlā me kēia makahiki.
Ka manawa hoʻouna: Mei-06-2022